D5 is a form of vitamin D used in medicine as an antitumor substance. The “raw material” for D5 is the sterol 7-dehydrositosterol.
What is vitamin D and its forms
Vitamin D (calciferol) is a group of fat-soluble prohormones whose most common forms are D2 (ergocalciferol) and D3 (cholecalciferol).
The human body is able to get the D-substance in two ways: from food and dietary supplements, as well as synthesize the substance in the skin under the influence of the sun.
The ability of the body to accumulate some D-reserves helps to maintain a healthy state of all systems and organs. In particular, calciferol is necessary for the regulation of the desired level of calcium and phosphorus in the blood. This useful substance also helps to absorb Ca from the intestine, plays an important role for the immune system, has a positive effect on neuromuscular functions, and reduces the risk of various kinds of inflammation and hypertension.
But the most important effect of vitamin D is the strengthening of bone tissue. If the body does not receive a sufficient amount of calciferol, the bones weaken, lose their ability to develop normally.
However, an overabundance, like the lack of a D-substance, is dangerous for the human body. Especially if the level of the substance reaches a toxic concentration. Meanwhile, calciferol is a biologically inert substance. For activation in the body, it must undergo a double hydroxylation reaction.
There are several forms of D-substance:
- D1 – a molecular compound of ergocalciferol and lamisterol;
- D2 – ergocalciferol;
- D3 – cholecalciferol, which in the skin is converted to 7-dehydrocholesterol;
- D4 – 22-dihydroerrgocalciferol;
- D5 – sitocalciferol, is transformed into 7-dehydrositosterol;
- D6 – pyridoxine, pyridoxal and pyridoxamine;
- D7 – ultraviolet light converts it into vitamin D3.
The most common forms of calciferol, as already noted, are D2 and D3. Vitamin D2 in significant doses is contained in plants and, therefore, a person is able to replenish his reserves from food. D3 is also inherent in certain products, and also forms in the body when the skin is exposed to sunlight. There are also methods for artificially synthesizing calciferol in the skin (for example, tanning beds) or food specially enriched with this useful substance.
As for vitamin D5, it is an artificial analogue of D3. What does it mean? Vitamin D5 is structurally similar to D3, both play a similar role for the human body. However, the D5 form is less toxic, and therefore is regularly used for medicinal purposes.
Specially replenish the reserves of vitamin D6 healthy person is not necessary. Lack of substance is diagnosed only in people with kidney disease and alcohol abusers. As for vitamin D7, then, according to nature, ultraviolet light transforms this form into useful D3.
All forms of vitamin D modern science distributes into groups. Between themselves, they differ in molecular structure, but the basis of each is the same molecule – calcitriol. Yes, and the functions in the body, they also perform identical. In search of the least toxic analogue of the D-substance (for therapeutic use), scientists have developed several “versions” of the vitamin. Today, more than 1500 analogues are known. The least toxic of these forms is D5, which has now “survived” a series of experiments to convince the scientific world of its effectiveness and safety. Now D5 is used for the prevention and treatment of cancer.
Sitocalciferol, or D5, is a synthetic “version” of vitamin D, more precisely, an analogue of D3. Both variants have similar structures, but the molecular formula of D5 was somewhat modified by artificial means. D5, like other forms of the D-substance, is the so-called prohormone, not a vitamin in the traditional concept. When consumed D5, the body absorbs it on the principle of hormones that control various functions. In pharmacology, vitamin D5 is known as dehydrotachysterol. In nature, 24-ethylcholecalciferol or citocalciferol is found in wheat oil.
As already noted, an excess of vitamin D, like any other type of hypervitaminosis, can be dangerous for the human body. Disturbance of the D-balance is fraught with serious consequences. And this:
- bone loss;
- nausea and vomiting, which can later lead to anorexia;
- impaired renal function.
Other symptoms include excessive urination, thirst, fatigue, weakness, headache, metallic taste and dry mouth, noise or tinnitus, dizziness.
However, when it comes to vitamin D5, one does not have to worry about such sad consequences. Due to reduced toxicity, it is this formula that is used in medicine, when medical therapy involves the use of high doses of vitamin. The likelihood of side effects after exceeding the daily norm of D5 is significantly lower than in comparison with other “versions” of vitamin.
How did the vitamin D5
The D5 form of the vitamin was developed and developed by a group of scientists from Illinois and Chicago. The researchers conducted a series of experiments proving the safety and efficacy of this substance in the treatment of various types of oncological diseases, especially breast, prostate and colon cancer.
D5 was developed as a safe analogue of a vitamin for medical use. This low-calcium version is the least toxic form of the vitamin and is therefore the safest.
The fact that people who eat foods rich in vitamin D and spend a lot of time in the sun are less prone to developing oncological diseases, has been known to science for a long time. At one time, practical experiments conducted in the laboratory proved the effectiveness of D3 in preventing the development of cancer. But at the same time, scientists are faced with another side of the effect of vitamin on the body. The required dose of D3, which is able to affect the cells, was so high and toxic that the researchers had to abandon the idea of using such therapy in practice. In order for cancer treatment to be effective, doses of D3 were required, which were hundreds of times the daily requirement. That is, theoretically, D3 is able to save from cancer, but the use of such therapy in practice is harmful to the body. At this stage of the study, the world has learned: vitamin D3 is not suitable for the real treatment and prevention of cancer.
After these experiments, scientists have set themselves another task – to find a safe alternative form of vitamin D that can perform the same functions, but be non-toxic. So the formula was derived D5, which at a sufficiently high concentration does not cause poisoning.
After the next series of tests, the effect of vitamin D5 on the development of cancer cells was established. The doses required for the treatment and prevention of the disease were determined experimentally. In medical circles, they talk about the efficacy of using D5-a substance for the prevention of colon, breast and prostate cancer. As for other types of oncology, it is still too early to say something unequivocally – research continues.
How to replenish stocks
As already noted, vitamin D5 is essentially an analogue of D3, in its chemical formula and mechanism of influence on the body is close to D2. And this means that to provide the body with vitamin D, it is enough to take any of the “versions” of the substance. And since D2 and D3 are the most common forms in nature, it is logical to replenish vitamin reserves from plant (D2) and animal (D3) sources. For this function, fish oil and fish, liver (animals and fish), cheese, egg yolks, mushrooms are excellent. Also, do not forget about sunlight – a free and most affordable way to synthesize calciferol in the body.
Instead of an epilogue
Most people do not need to take artificial vitamin supplements – just stick to a healthy lifestyle, a balanced diet and the correct daily regimen. Pregnant women, the elderly and the sick may temporarily increase the daily requirement of vitamin D, but the doctor must determine and adjust the dose. As for the D5 substance, do not worry and specifically look for dihydrotachysterol drugs in pharmacies.
Remember: this is an artificially derived analogue of a natural substance, which is resorted to in exceptional cases.
In general, it is better to spend time not on the queue in pharmacies, but on pleasant walks in the sun – and it does not matter what time of year it is outside the window.